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  • The Food and Drug Administration, FDA, has approved the drug Vivitrol to the treatment of opioid dependence as outlined by a news release by them on 10-12-2010.

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    Researchers discovered that participants investing in this drug to get a year, dropped a few pounds within a month and have kept the load off through the entire 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which might be made up of several active ingredient, which might make them more effective and safer.

    Combo-pilling will be the newest fad or also the newest in the future under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that as of right now there aren't long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise hypertension and heartrate, and mustn't be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    From a psychiatric perspective, evidence suggests that the ordinary neural mechanism for goal-directed behavior has been hijacked from the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus and also the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).