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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) of greater than 27, given that they also suffer from weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% instead of participants who have been given placebos) within a 12- month period, while a different study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it one should err assisting caution and allow the FDA do its job and demand some investigation be done in order that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on their own medications.

    Researchers found out that participants taking this drug for a year, dropped a few pounds within a month and have kept the load off through the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which might be made up of many active ingredient, which might make them far better and safer.

    Combo-pilling will be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that since right now there are not any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise hypertension and pulse rate, and must not be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

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